SYNDIG1

Across TCGA patient cohorts, SYNDIG1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,986 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SYNDIG1-associated genes across cancer lineages are CACNA1I, KIAA0930, and RBX1. Each is linked with SYNDIG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNDIG1-to-partner and partner-to-SYNDIG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYNDIG1 versus CACNA1I in GBM, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNDIG1→partner) and Y-score (partner→SYNDIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CACNA1I →	+0.628	+0.322	<.001	.001	3	1
GBM	KIAA0930 →	+0.425	+0.367	.001	<.001	3	1
GBM	RBX1 →	+0.261	+0.371	.002	<.001	3	1
GBM	MANBAL →	-0.263	-0.306	.001	.001	3	1
GBM	PPP1R16B →	+1.047	+0.336	.001	.002	3	1
GBM	HTR2A →	+0.755	+0.368	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,986 associations by consensus.

SYNDIG1 vs CACNA1I — GBM

Explore this scatter interactively →