SYNDIG1

Across TCGA patient cohorts, SYNDIG1 protein abundance is significantly associated with the protein abundance of many other proteins, with 8,256 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SYNDIG1-associated proteins across cancer lineages are RBMX2_S314, RBP7, and RBM14_T206. Each is linked with SYNDIG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNDIG1-to-partner and partner-to-SYNDIG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYNDIG1 versus RBMX2_S314 in GBM, with a Pearson correlation of -0.33.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNDIG1→partner) and Y-score (partner→SYNDIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RBMX2_S314 →	-0.392	-0.311	<.001	<.001	3	1
GBM	RBP7 →	+0.629	+0.343	<.001	<.001	3	1
GBM	RBM14_T206 →	-0.177	-0.320	<.001	<.001	3	1
GBM	RBM15_S109 →	-0.411	-0.345	<.001	.001	3	1
GBM	RBM15_S656 →	-0.244	-0.244	.002	.003	3	1
GBM	RBM15_S686 →	-0.362	-0.272	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,256 associations by consensus.

SYNDIG1 vs RBMX2_S314 — GBM

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