SYNDIG1

Across TCGA patient cohorts, SYNDIG1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNDIG1-associated genes across cancer lineages are Rictor_pT1135, Bim, and 4E-BP1_pT37_T46. Each is linked with SYNDIG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNDIG1-to-partner and partner-to-SYNDIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by SYNDIG1-low versus SYNDIG1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNDIG1→partner) and Y-score (partner→SYNDIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rictor_pT1135 →	-0.147	-2.485	.014	.001	3	2
SKCM	Bim →	+0.259	+1.874	.012	.047	3	2
SKCM	4E-BP1_pT37_T46 →	-0.436	-2.459	.005	.018	3	2
SKCM	Caveolin-1 →	-0.607	-1.874	.012	.047	3	2
SKCM	Di-Ras3 →	+0.144	+2.713	.009	.003	3	2
UCEC	eEF2 →	+0.327	+1.847	.012	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Rictor_pT1135 by SYNDIG1 expression — SKCM

Explore this box plot interactively →