SYNDIG1

Across TCGA cell cohorts, SYNDIG1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SYNDIG1-associated genes across cancer lineages are GABRA4, TXNDC8, and LCN9. Each is linked with SYNDIG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNDIG1-to-partner and partner-to-SYNDIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRA4 grouped by SYNDIG1-low versus SYNDIG1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNDIG1→partner) and Y-score (partner→SYNDIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GABRA4 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	TXNDC8 →	+0.016	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	LCN9 →	+0.030	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	PROP1 →	+0.012	+4.867	.001	.009	3	1
BLOOD_Lymphoma	KRTAP21-2 →	+0.140	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR10J1 →	+0.022	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GABRA4 by SYNDIG1 expression — OESOPHAGUS

Explore this box plot interactively →