SYNCRIP

Across TCGA patient cohorts, SYNCRIP mutation is significantly associated with the RNA expression of many other genes, with 2,582 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNCRIP-associated genes across cancer lineages are PTMAP6, RN7SL553P, and MIR3651. Each is linked with SYNCRIP in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNCRIP-to-partner and partner-to-SYNCRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTMAP6 grouped by SYNCRIP-low versus SYNCRIP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNCRIP→partner) and Y-score (partner→SYNCRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PTMAP6 →	+0.226	+3.427	.008	.006	3	2
SKCM	RN7SL553P →	+0.082	+4.469	<.001	.006	3	2
SKCM	MIR3651 →	+0.686	+3.881	<.001	.004	3	2
LGG	RNU6-23P →	+0.405	+5.529	<.001	.004	3	2
LGG	LINC02230 →	+0.145	+5.602	<.001	.004	3	2
CESC	QRSL1P1 →	+0.107	+4.177	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,582 associations by consensus.

PTMAP6 by SYNCRIP expression — SKCM

Explore this box plot interactively →