Across TCGA patient cohorts, SYN3 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,708 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SYN3-associated proteins across cancer lineages are ARHGEF7, PMM2, and ARHGEF17. Each is linked with SYN3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SYN3-to-partner and partner-to-SYN3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SYN3→partner) and Y-score (partner→SYN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGEF7 →	+0.262	+0.951	<.001	<.001	3	4
GBM	PMM2 →	-0.452	-1.156	<.001	<.001	3	4
CCRCC	ARHGEF17 →	+0.430	+0.248	<.001	<.001	3	4
PDAC	RNF213 →	-0.327	-0.319	<.001	.002	3	4
CCRCC	RPL5 →	-0.206	-0.208	<.001	<.001	3	4
PDAC	SEPTIN11 →	+0.375	+0.265	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,708 associations by consensus.

Exploration

SYN3 survival (RNA) · tumor vs normal (RNA) · all SYN3 data types