SYMPK

Across TCGA cell cohorts, SYMPK mutation is significantly associated with the RNA expression of many other genes, with 519 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYMPK-associated genes across cancer lineages are OR12D2, MMP26, and SALL3. Each is linked with SYMPK in more than 1 cancer types. Because this analysis shows association rather than direction, both SYMPK-to-partner and partner-to-SYMPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D2 grouped by SYMPK-low versus SYMPK-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYMPK→partner) and Y-score (partner→SYMPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR12D2 →	+0.094	+4.343	<.001	.002	3	2
BLOOD_Myeloma	MMP26 →	+0.026	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SALL3 →	+0.060	+4.807	<.001	.006	3	1
BLOOD_Myeloma	RBP3 →	+0.006	+4.807	<.001	.006	3	1
URINARY_TRACT	OR13C5 →	+0.760	+5.087	<.001	.004	3	1
CNS	OR3A1 →	+0.046	+4.044	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 519 associations by consensus.

OR12D2 by SYMPK expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →