SYK

Across TCGA pan-cancer cohorts, SYK mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SYK’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SYK mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SYK is over-expressed in tumor.

COAD, CCRCC, and OV are the cancer types where SYK tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYK mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.257	<.001	9	view →
CCRCC	Male	II,III,IV	+0.301	<.001	7	view →
OV	All	All	+0.462	.004	2	view →
HNSC	All	All	+0.119	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SYK–COAD

Open the COAD breakdown →