SYK

Across TCGA pan-cancer cohorts, SYK RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SYK data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SYK RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SYK expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and LGG are the cancer types where SYK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.754	0.576	<.001	69	view →
KIRC	DFS	Quartile	II,III,IV	0.794	0.481	.006	53	view →
LGG	DFS	Median	All	0.673	0.806	<.001	46	view →
CHOL	DFS	Quartile	All	0.780	0.142	.002	36	view →
LAML	DFS	Median	All	0.243	0.524	.001	28	view →
UVM	DFS	Tertile	All	0.332	0.640	.007	16	view →
LUAD	OS	Quartile	II,III,IV	0.867	0.627	.006	14	view →
STAD	DFS	Tertile	III,IV	0.544	0.235	.030	12	view →
OV	OS	Tertile	All	0.875	0.786	.030	12	view →
GBM	DFS	Median	All	0.155	0.248	.001	12	view →
SKCM	OS	Median	All	0.410	0.275	.011	11	view →
ACC	OS	Tertile	IV	0.404	0.838	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SYK–HNSC (DFS)

Open the HNSC breakdown →