SYK

Across TCGA patient cohorts, SYK protein abundance is significantly associated with the RNA expression of many other genes, with 18,047 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SYK-associated genes across cancer lineages are CD226, RASAL3, and TNFSF8. Each is linked with SYK in more than 7 cancer types. Because this analysis shows association rather than direction, both SYK-to-partner and partner-to-SYK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYK versus CD226 in UCEC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYK→partner) and Y-score (partner→SYK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD226 →	+0.711	+0.337	.005	.001	3	8
GBM	RASAL3 →	+0.916	+0.719	<.001	<.001	3	7
GBM	TNFSF8 →	+1.022	+0.729	<.001	<.001	3	7
LSCC	LPXN →	+0.855	+0.463	<.001	<.001	3	7
BRCA	CD5 →	+1.266	+0.437	<.001	<.001	3	7
UCEC	ZAP70 →	+1.389	+0.402	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,047 associations by consensus.

SYK vs CD226 — UCEC

Explore this scatter interactively →