SYK

Across TCGA patient cohorts, SYK mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYK-associated genes across cancer lineages are PCNA, eEF2, and MEK1. Each is linked with SYK in more than 2 cancer types. Because this analysis shows association rather than direction, both SYK-to-partner and partner-to-SYK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SYK-low versus SYK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYK→partner) and Y-score (partner→SYK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.175	+1.700	.013	.040	3	3
SKCM	eEF2 →	+0.425	+3.321	.003	.009	3	2
UCEC	MEK1 →	+0.371	+2.415	.002	.003	3	2
UCEC	p62 Lck ligand →	+0.263	+1.687	.014	.013	3	2
UCEC	TFRC →	+0.589	+1.652	<.001	.006	3	2
UCEC	Cyclin-B1 →	+0.382	+2.000	.039	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PCNA by SYK expression — UCEC

Explore this box plot interactively →