SYK

Across TCGA cell cohorts, SYK mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SYK-associated genes across cancer lineages are TBR1, DEFA4, and C9orf153. Each is linked with SYK in more than 1 cancer types. Because this analysis shows association rather than direction, both SYK-to-partner and partner-to-SYK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBR1 grouped by SYK-low versus SYK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYK→partner) and Y-score (partner→SYK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBR1 →	+0.040	+3.333	<.001	.009	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	C9orf153 →	+0.255	+3.497	<.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1
BLOOD_Leukemia	AQP12A →	+0.112	+4.269	<.001	.002	3	1
SKIN	BSND →	+0.007	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

TBR1 by SYK expression — LARGE_INTESTINE

Explore this box plot interactively →