SYCP2L

Across TCGA patient cohorts, SYCP2L mutation is significantly associated with the RNA expression of many other genes, with 4,918 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYCP2L-associated genes across cancer lineages are GET3, POLA2, and NDUFV2P1. Each is linked with SYCP2L in more than 3 cancer types. Because this analysis shows association rather than direction, both SYCP2L-to-partner and partner-to-SYCP2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GET3 grouped by SYCP2L-low versus SYCP2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCP2L→partner) and Y-score (partner→SYCP2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GET3 →	+0.388	+1.787	<.001	<.001	3	4
UCEC	POLA2 →	+0.519	+2.584	<.001	<.001	3	4
UCEC	NDUFV2P1 →	+0.370	+1.551	.002	.002	3	4
UCEC	PUSL1 →	+0.464	+2.662	<.001	<.001	3	4
UCEC	AURKB →	+0.644	+4.010	<.001	<.001	3	3
UCEC	RAD23A →	+0.395	+1.776	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,918 associations by consensus.

GET3 by SYCP2L expression — UCEC

Explore this box plot interactively →