SYCP2L

Across TCGA cell cohorts, SYCP2L mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SYCP2L-associated genes across cancer lineages are CASP12, OPN1LW, and SPATA48. Each is linked with SYCP2L in more than 1 cancer types. Because this analysis shows association rather than direction, both SYCP2L-to-partner and partner-to-SYCP2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CASP12 grouped by SYCP2L-low versus SYCP2L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCP2L→partner) and Y-score (partner→SYCP2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CASP12 →	+0.033	+3.684	<.001	.006	3	2
LUNG_NSCLC_LUAD	OPN1LW →	+0.057	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SPATA48 →	+0.009	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	GPR33 →	+0.023	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR1D4 →	+0.046	+4.662	<.001	.005	3	1
LARGE_INTESTINE	CSN2 →	+0.031	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

CASP12 by SYCP2L expression — LARGE_INTESTINE

Explore this box plot interactively →