Across TCGA patient cohorts, SYCP2 mutation is significantly associated with the RNA expression of many other genes, with 4,660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYCP2-associated genes across cancer lineages are NDUFA6, PARP2, and MMP7. Each is linked with SYCP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYCP2-to-partner and partner-to-SYCP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCP2→partner) and Y-score (partner→SYCP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA6 →	+0.478	+1.917	<.001	<.001	3	4
UCEC	PARP2 →	+0.328	+1.357	<.001	<.001	3	4
BLCA	MMP7 →	-1.983	-3.459	.006	.005	3	3
UCEC	RCC1 →	+0.289	+1.633	.006	.001	3	3
UCEC	SF3A3 →	+0.223	+1.579	.008	.002	3	3
UCEC	SETD3 →	+0.322	+1.846	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,660 associations by consensus.

Exploration

SYCP2 survival (RNA) · tumor vs normal (RNA) · all SYCP2 data types