SYCN

Across TCGA pan-cancer cohorts, SYCN Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SYCN data layer compared with 18 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SYCN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SYCN expression acts as an unfavorable survival marker.

COAD, ACC, and ESCA are the cancer types where SYCN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.168	0.806	.002	24	view →
ACC	OS	Median	All	0.188	0.820	<.001	12	view →
ESCA	DFS	Median	II,III,IV	0.120	0.526	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SYCN–COAD (OS)

Open the COAD breakdown →