SYCE2

Across TCGA patient cohorts, SYCE2 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYCE2-associated genes across cancer lineages are SNRPCP20, OR5B17, and MIR425. Each is linked with SYCE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYCE2-to-partner and partner-to-SYCE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPCP20 grouped by SYCE2-low versus SYCE2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCE2→partner) and Y-score (partner→SYCE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNRPCP20 →	+0.379	+3.831	<.001	.007	3	2
COAD	OR5B17 →	+0.044	+6.149	<.001	<.001	3	1
COAD	MIR425 →	+0.947	+4.437	<.001	.002	3	1
COAD	MIR147A →	+0.486	+4.308	<.001	.009	3	1
COAD	PSAT1P4 →	+0.371	+4.463	<.001	.002	3	1
COAD	GRPEL2P2 →	+0.245	+3.910	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

SNRPCP20 by SYCE2 expression — COAD

Explore this box plot interactively →