SYCE2

Across TCGA pan-cancer cohorts, SYCE2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SYCE2 data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SYCE2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SYCE2 expression acts as an unfavorable survival marker, although some lineages such as CESC and BLCA show a favorable association.

ACC, CESC, and COAD are the cancer types where SYCE2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.179	0.707	<.001	136	view →
CESC	OS	Median	All	0.701	0.438	<.001	98	view →
COAD	OS	Tertile	III,IV	0.532	0.935	<.001	92	view →
KIRC	OS	Median	All	0.538	0.711	<.001	84	view →
KICH	DFS	Quartile	III,IV	0.131	1.000	.002	78	view →
BLCA	OS	Tertile	All	0.583	0.311	<.001	77	view →
KIRP	DFS	Quartile	II,III,IV	0.203	0.955	.001	77	view →
MESO	OS	Tertile	All	0.447	0.642	.002	64	view →
SCLC	DFS	Median	II,III,IV	0.535	0.171	.001	49	view →
LGG	OS	Tertile	All	0.872	0.711	<.001	41	view →
UVM	DFS	Median	III,IV	0.251	0.718	.002	38	view →
PRAD	DFS	Tertile	All	0.832	0.947	<.001	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SYCE2–ACC (DFS)

Open the ACC breakdown →