SYCE2

Across TCGA cell cohorts, SYCE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,376 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYCE2-associated GO terms across cancer lineages are Positive regulation of stem cell population maintenance, Positive regulation of double-strand break repair, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with SYCE2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SYCE2-to-partner and partner-to-SYCE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of stem cell population maintenance grouped by SYCE2-low versus SYCE2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYCE2→partner) and Y-score (partner→SYCE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of stem cell population maintenance →	+0.097	+0.993	<.001	<.001	3	9
BONE	Positive regulation of double-strand break repair →	+0.079	+0.746	<.001	.001	3	9
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.123	+0.805	<.001	<.001	3	9
BONE	Regulation of stem cell population maintenance →	+0.070	+0.596	<.001	.003	3	8
LUNG_SCLC	Regulation of cytokine production involved in immune response →	-0.064	-0.861	<.001	<.001	3	8
LIVER	Hormone metabolic process →	-0.115	-0.613	.005	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,376 associations by consensus.

Positive regulation of stem cell population maintenance by SYCE2 expression — LUNG_SCLC

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