SYAP1

Across TCGA pan-cancer cohorts, SYAP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SYAP1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SYAP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SYAP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where SYAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.391	0.209	.002	40	view →
CCRCC	OS	Median	II,III,IV	0.339	1.000	.003	35	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.492	.008	26	view →
LUAD	OS	Median	All	1.000	0.924	.002	6	view →
GBM	DFS	Median	All	0.408	0.224	.046	4	view →
HNSC	OS	Median	II,III,IV	0.953	1.000	.019	2	view →
LSCC	OS	Tertile	All	0.853	0.941	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SYAP1–PDAC (DFS)

Open the PDAC breakdown →