SVOP

Across TCGA patient cohorts, SVOP mutation is significantly associated with the RNA expression of many other genes, with 2,951 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SVOP-associated genes across cancer lineages are RPL23AP54, COX15, and GPR180. Each is linked with SVOP in more than 1 cancer types. Because this analysis shows association rather than direction, both SVOP-to-partner and partner-to-SVOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP54 grouped by SVOP-low versus SVOP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVOP→partner) and Y-score (partner→SVOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL23AP54 →	+0.030	+2.943	.001	.009	3	2
UCEC	COX15 →	+0.472	+2.592	<.001	<.001	3	2
UCEC	GPR180 →	+0.475	+2.201	<.001	<.001	3	2
UCEC	BUB3 →	+0.500	+2.981	<.001	<.001	3	2
UCEC	NTAN1 →	+0.520	+3.201	<.001	<.001	3	2
UCEC	SAP30 →	+0.489	+2.606	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,951 associations by consensus.

RPL23AP54 by SVOP expression — SKCM

Explore this box plot interactively →