SVOP

Across TCGA pan-cancer cohorts, SVOP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SVOP’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SVOP RNA is repressed in tumor relative to normal tissue. In most cancer types SVOP is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRP, and LUSC are the cancer types where SVOP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SVOP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.410	<.001	11	view →
KIRP	All	II,III,IV	−0.318	.001	9	view →
LUSC	All	II,III,IV	+0.052	.005	4	view →
CHOL	All	All	−0.276	<.001	3	view →
BRCA	Female	All	+0.104	.042	2	view →
PRAD	All	All	−0.088	.004	2	view →
HNSC	Male	All	−0.048	.034	2	view →
THCA	All	All	−0.010	.009	2	view →
READ	Female	All	−0.590	.003	1	view →
STAD	All	III,IV	−0.333	.037	1	view →
ESCA	All	All	−0.265	.013	1	view →
KICH	All	All	−0.113	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SVOP–COAD

Open the COAD breakdown →