SVOP

Across TCGA patient cohorts, SVOP mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SVOP-associated genes across cancer lineages are INPP4B, S6_pS235_S236, and Shc_pY317. Each is linked with SVOP in more than 1 cancer types. Because this analysis shows association rather than direction, both SVOP-to-partner and partner-to-SVOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SVOP-low versus SVOP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVOP→partner) and Y-score (partner→SVOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.244	-2.115	.036	.017	3	2
SKCM	S6_pS235_S236 →	+0.550	+2.820	.023	.035	3	1
SKCM	Shc_pY317 →	+0.227	+3.017	.036	.019	3	1
UCEC	14-3-3_beta →	-0.095	-2.558	.008	.010	3	1
UCEC	EGFR_pY1068 →	-0.230	-1.700	.010	.042	3	1
UCEC	eIF4E →	+0.168	+2.000	.027	.030	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

INPP4B by SVOP expression — UCEC

Explore this box plot interactively →