SVOP

Across TCGA cell cohorts, SVOP mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SVOP-associated genes across cancer lineages are CT47A6, NLRP9, and CRYBA4. Each is linked with SVOP in more than 1 cancer types. Because this analysis shows association rather than direction, both SVOP-to-partner and partner-to-SVOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT47A6 grouped by SVOP-low versus SVOP-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVOP→partner) and Y-score (partner→SVOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CT47A6 →	+0.676	+4.981	<.001	.008	3	2
LUNG_SCLC	NLRP9 →	+0.034	+3.256	<.001	.005	3	1
LUNG_SCLC	CRYBA4 →	+0.125	+3.949	<.001	.001	3	1
LUNG_SCLC	AADACL4 →	+0.079	+3.232	.001	.008	3	1
LUNG_SCLC	KRTAP1-4 →	+0.163	+3.584	<.001	.003	3	1
LUNG_SCLC	LRRC3C →	+0.176	+3.491	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CT47A6 by SVOP expression — CNS

Explore this box plot interactively →