Across TCGA patient cohorts, SVIP RNA expression is significantly associated with the protein abundance of many other proteins, with 13,483 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SVIP-associated proteins across cancer lineages are MMP14, DDAH1, and C11orf58. Each is linked with SVIP in more than 5 cancer types. Because this analysis shows association rather than direction, both SVIP-to-partner and partner-to-SVIP results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SVIP→partner) and Y-score (partner→SVIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MMP14 →	-0.418	-0.361	<.001	.002	3	6
HNSC	DDAH1 →	+0.733	+1.239	<.001	<.001	3	6
OV	C11orf58 →	+0.386	+0.711	<.001	<.001	3	5
LSCC	CSTA →	-1.229	-1.049	<.001	<.001	3	5
LUAD	PLEKHA7_S536 →	+1.055	+0.680	<.001	.001	3	5
BRCA	MLPH →	+0.822	+0.757	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,483 associations by consensus.

Exploration

SVIP survival (RNA) · tumor vs normal (RNA) · all SVIP data types