Across TCGA patient cohorts, SVIP protein abundance is significantly associated with the RNA expression of many other genes, with 8,850 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SVIP-associated genes across cancer lineages are FRMD6, CLEC18B, and PDPN. Each is linked with SVIP in more than 4 cancer types. Because this analysis shows association rather than direction, both SVIP-to-partner and partner-to-SVIP results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVIP→partner) and Y-score (partner→SVIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FRMD6 →	-0.930	-0.616	.003	<.001	3	5
OV	CLEC18B →	-0.925	-0.455	.004	.009	3	4
OV	PDPN →	-1.428	-0.593	.001	<.001	3	4
GBM	ENPP4 →	+1.127	+0.594	<.001	.001	3	4
HNSC	ATP8A1 →	+0.850	+0.538	<.001	.001	3	4
LSCC	RPS14P4 →	-0.870	-0.404	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,850 associations by consensus.

Exploration

SVIP survival (RNA) · tumor vs normal (RNA) · all SVIP data types