SVEP1

Across TCGA pan-cancer cohorts, SVEP1 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated SVEP1 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SVEP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SVEP1 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

UVM, KIRP, and STAD are the cancer types where SVEP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.075	0.859	<.001	36	view →
KIRP	OS	Median	All	0.556	0.951	<.001	36	view →
STAD	DFS	Median	All	0.866	0.366	<.001	36	view →
UCEC	DFS	Median	All	0.815	0.611	<.001	28	view →
COAD	OS	Median	All	0.286	0.715	.021	15	view →
MESO	DFS	Median	II,III,IV	0.039	0.407	<.001	12	view →
BRCA	OS	Median	III,IV	0.233	0.833	.003	12	view →
HNSC	DFS	Median	IV	0.260	0.594	.003	12	view →
PRAD	DFS	Median	All	0.422	0.888	<.001	6	view →
LUSC	DFS	Median	All	0.685	0.358	.014	6	view →
ESCA	DFS	Median	All	0.199	0.540	.004	6	view →
ACC	DFS	Median	All	0.148	0.563	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

SVEP1–UVM (OS)

Open the UVM breakdown →