SVEP1

Across TCGA pan-cancer cohorts, SVEP1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SVEP1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SVEP1 RNA is repressed in tumor relative to normal tissue. In most cancer types SVEP1 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and KIRC are the cancer types where SVEP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SVEP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−2.675	<.001	11	view →
THCA	Female	II,III,IV	−2.040	<.001	11	view →
KIRC	Male	II,III,IV	−1.748	<.001	11	view →
LUAD	Female	III,IV	−1.998	<.001	9	view →
KIRP	Female	All	−1.761	<.001	9	view →
COAD	Female	II,III,IV	−1.113	<.001	9	view →
LUSC	Female	All	−2.217	<.001	7	view →
BRCA	All	III,IV	−2.817	<.001	6	view →
UCEC	All	III,IV	−2.187	<.001	6	view →
LIHC	Male	All	−0.917	<.001	6	view →
READ	Female	All	−1.748	.007	2	view →
KICH	Female	II,III,IV	+1.458	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SVEP1–BLCA

Open the BLCA breakdown →