SVEP1

Across TCGA pan-cancer cohorts, SVEP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SVEP1 data layer compared with 23 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SVEP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SVEP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where SVEP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.442	0.919	.009	16	view →
HNSC	OS	Median	All	0.913	0.792	.008	10	view →
LUAD	DFS	Median	All	0.947	0.668	.014	7	view →
GBM	OS	Quartile	All	0.742	0.252	.023	2	view →
PDAC	DFS	Median	II,III,IV	0.662	0.882	.012	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SVEP1–CCRCC (DFS)

Open the CCRCC breakdown →