SVEP1

Across TCGA patient cohorts, SVEP1 mutation is significantly associated with the RNA expression of many other genes, with 7,580 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SVEP1-associated genes across cancer lineages are NDUFA12, MRPL18, and PIMREG. Each is linked with SVEP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SVEP1-to-partner and partner-to-SVEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA12 grouped by SVEP1-low versus SVEP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVEP1→partner) and Y-score (partner→SVEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA12 →	+0.192	+0.928	.002	.006	3	6
UCEC	MRPL18 →	+0.285	+1.747	<.001	<.001	3	5
UCEC	PIMREG →	+0.585	+1.302	<.001	<.001	3	5
UCEC	KLHL3 →	-0.445	-1.612	<.001	<.001	3	5
COAD	THRB →	-0.587	-2.979	<.001	<.001	3	5
UCEC	CENPU →	+0.608	+1.324	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,580 associations by consensus.

NDUFA12 by SVEP1 expression — UCEC

Explore this box plot interactively →