SVEP1

Across TCGA patient cohorts, SVEP1 mutation is significantly associated with the total protein of many other genes, with 106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SVEP1-associated genes across cancer lineages are 14-3-3_beta, eEF2, and ACVRL1. Each is linked with SVEP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SVEP1-to-partner and partner-to-SVEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SVEP1-low versus SVEP1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVEP1→partner) and Y-score (partner→SVEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	14-3-3_beta →	-0.135	-2.000	.036	.025	3	5
COAD	eEF2 →	+0.271	+1.511	.005	.018	3	5
COAD	ACVRL1 →	-0.202	-2.794	.014	.003	2	6
UCEC	ATM →	-0.346	-1.419	.001	.003	3	5
LUSC	TFRC →	+0.648	+3.169	.009	.018	3	4
UCEC	Cyclin-B1 →	+0.533	+2.700	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

14-3-3_beta by SVEP1 expression — STAD

Explore this box plot interactively →