SVEP1

Across TCGA cell cohorts, SVEP1 mutation is significantly associated with the RNA expression of many other genes, with 587 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SVEP1-associated genes across cancer lineages are CATSPER4, ATP5ME, and IL22. Each is linked with SVEP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SVEP1-to-partner and partner-to-SVEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CATSPER4 grouped by SVEP1-low versus SVEP1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SVEP1→partner) and Y-score (partner→SVEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CATSPER4 →	+0.042	+2.321	<.001	.008	3	3
SKIN	ATP5ME →	+0.412	+3.321	.008	.003	3	3
BLOOD_Leukemia	IL22 →	+0.016	+3.762	<.001	.007	3	3
LUNG_NSCLC_LUAD	TSPAN16 →	+0.035	+2.157	<.001	<.001	3	3
SOFT_TISSUE	NLRP5 →	+0.069	+2.321	.008	.007	3	2
SOFT_TISSUE	ZADH2 →	+0.888	+3.303	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 587 associations by consensus.

CATSPER4 by SVEP1 expression — BLOOD_Lymphoma

Explore this box plot interactively →