SV2C

Across TCGA pan-cancer cohorts, SV2C Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SV2C data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SV2C Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SV2C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LIHC, and COAD are the cancer types where SV2C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.911	0.612	.009	28	view →
LIHC	OS	Median	II,III,IV	0.028	0.772	<.001	24	view →
COAD	OS	Median	IV	0.056	0.659	.002	21	view →
SKCM	OS	Median	IV	0.179	0.755	<.001	7	view →
OV	DFS	Median	III,IV	0.160	0.532	.004	6	view →
SARC	DFS	Median	All	0.217	0.614	.014	6	view →
BLCA	OS	Median	All	0.204	0.687	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SV2C–UCEC (DFS)

Open the UCEC breakdown →