SV2C

Across TCGA pan-cancer cohorts, SV2C RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SV2C’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where SV2C RNA is repressed in tumor relative to normal tissue. In most cancer types SV2C is over-expressed in tumor, although a few such as STAD and BRCA show the opposite, repressed pattern.

STAD, BRCA, and COAD are the cancer types where SV2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SV2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	−0.420	.004	6	view →
BRCA	All	All	−0.186	<.001	6	view →
COAD	All	All	−0.120	.016	3	view →
PRAD	All	All	+0.602	<.001	2	view →
LUAD	All	IV	−0.105	.036	2	view →
THCA	Male	III,IV	−0.065	.006	2	view →
KIRC	Male	II,III,IV	+0.060	.011	2	view →
ESCA	All	All	−0.546	.049	1	view →
READ	All	II,III,IV	−0.277	.019	1	view →
CHOL	All	All	+0.162	.029	1	view →
HNSC	Female	III,IV	+0.073	.045	1	view →
KICH	All	III,IV	−0.051	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SV2C–STAD

Open the STAD breakdown →