SV2C

Across TCGA patient cohorts, SV2C protein abundance is significantly associated with the RNA expression of many other genes, with 3,643 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SV2C-associated genes across cancer lineages are SNRPD3, PRODH, and SEZ6L. Each is linked with SV2C in more than 1 cancer types. Because this analysis shows association rather than direction, both SV2C-to-partner and partner-to-SV2C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SV2C versus SNRPD3 in GBM, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2C→partner) and Y-score (partner→SV2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNRPD3 →	+0.291	+0.494	.002	.004	3	1
GBM	PRODH →	+0.824	+0.898	<.001	<.001	3	1
GBM	SEZ6L →	+1.381	+0.602	.003	.001	3	1
GBM	SOX10 →	+1.233	+0.768	<.001	<.001	3	1
GBM	SLC16A8 →	+0.486	+0.589	.001	.001	3	1
GBM	SEPTIN3 →	+1.062	+1.019	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,643 associations by consensus.

SV2C vs SNRPD3 — GBM

Explore this scatter interactively →