SV2C

Across TCGA patient cohorts, SV2C mutation is significantly associated with the RNA expression of many other genes, with 4,625 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SV2C-associated genes across cancer lineages are RNU2-27P, SDHB, and DLST. Each is linked with SV2C in more than 3 cancer types. Because this analysis shows association rather than direction, both SV2C-to-partner and partner-to-SV2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-27P grouped by SV2C-low versus SV2C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2C→partner) and Y-score (partner→SV2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU2-27P →	+0.661	+3.321	.004	.009	3	4
COAD	SDHB →	+0.451	+2.614	<.001	.005	3	3
COAD	DLST →	+0.432	+2.605	<.001	.005	3	3
COAD	MRPL35 →	+0.495	+2.634	<.001	.005	3	3
COAD	EIF2S1 →	+0.529	+3.348	<.001	.004	3	3
COAD	TTC5 →	+0.410	+2.920	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,625 associations by consensus.

RNU2-27P by SV2C expression — COAD

Explore this box plot interactively →