SV2C

Across TCGA patient cohorts, SV2C mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SV2C-associated genes across cancer lineages are JNK2, PRAS40_pT246, and XBP1. Each is linked with SV2C in more than 2 cancer types. Because this analysis shows association rather than direction, both SV2C-to-partner and partner-to-SV2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SV2C-low versus SV2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2C→partner) and Y-score (partner→SV2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.221	+2.169	<.001	<.001	3	3
UCEC	PRAS40_pT246 →	+0.118	+1.247	.011	.041	3	3
COAD	XBP1 →	+0.266	+2.182	<.001	.033	3	2
COAD	Caveolin-1 →	-0.731	-3.169	.014	.018	3	2
COAD	c-Kit →	-0.610	-3.000	.015	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.126	-1.353	.006	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

JNK2 by SV2C expression — UCEC

Explore this box plot interactively →