SV2C

Across TCGA cell cohorts, SV2C mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SV2C-associated genes across cancer lineages are HTR3D, C6, and PRR27. Each is linked with SV2C in more than 1 cancer types. Because this analysis shows association rather than direction, both SV2C-to-partner and partner-to-SV2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR3D grouped by SV2C-low versus SV2C-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2C→partner) and Y-score (partner→SV2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HTR3D →	+0.008	+3.925	<.001	.006	3	2
LUNG_SCLC	C6 →	+0.300	+3.025	<.001	.002	3	2
PANCREAS	PRR27 →	+0.023	+5.614	<.001	.002	3	1
PANCREAS	IQCM →	+0.163	+5.000	<.001	.006	3	1
BLOOD_Leukemia	RERGL →	+1.409	+3.017	<.001	.007	3	1
BLOOD_Leukemia	PRB2 →	+0.102	+2.906	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

HTR3D by SV2C expression — BLOOD_Lymphoma

Explore this box plot interactively →