SV2A

Across TCGA patient cohorts, SV2A mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SV2A-associated genes across cancer lineages are C-Raf, Cyclin-B1, and MEK1. Each is linked with SV2A in more than 3 cancer types. Because this analysis shows association rather than direction, both SV2A-to-partner and partner-to-SV2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SV2A-low versus SV2A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SV2A→partner) and Y-score (partner→SV2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	C-Raf →	+0.215	+2.584	.001	.010	3	4
UCEC	Cyclin-B1 →	+0.651	+2.137	<.001	.001	3	4
UCEC	MEK1 →	+0.373	+1.765	.002	.013	3	3
UCEC	4E-BP1 →	+0.342	+2.807	<.001	.002	3	3
UCEC	Ku80 →	+0.339	+2.920	<.001	<.001	3	2
STAD	BRCA2 →	-0.169	-3.169	.004	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

C-Raf by SV2A expression — STAD

Explore this box plot interactively →