SUZ12P1

Across TCGA patient cohorts, SUZ12P1 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUZ12P1-associated genes across cancer lineages are SPATA31A5, RN7SKP214, and RNU6-11P. Each is linked with SUZ12P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUZ12P1-to-partner and partner-to-SUZ12P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31A5 grouped by SUZ12P1-low versus SUZ12P1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUZ12P1→partner) and Y-score (partner→SUZ12P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SPATA31A5 →	+0.009	+7.640	<.001	.009	3	1
UCEC	RN7SKP214 →	+0.309	+2.656	<.001	.008	3	1
UCEC	RNU6-11P →	+0.421	+2.947	.001	.003	3	1
UCEC	RNU6-879P →	+0.488	+2.903	.006	.004	3	1
UCEC	RNA5SP248 →	+0.400	+2.656	.003	.008	3	1
UCEC	RNU6-4P →	+0.655	+2.872	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

SPATA31A5 by SUZ12P1 expression — BLCA

Explore this box plot interactively →