SUZ12

Across TCGA patient cohorts, SUZ12 protein abundance is significantly associated with the RNA expression of many other genes, with 17,274 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SUZ12-associated genes across cancer lineages are KIF2C, GINS1, and MCM3. Each is linked with SUZ12 in more than 8 cancer types. Because this analysis shows association rather than direction, both SUZ12-to-partner and partner-to-SUZ12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SUZ12 versus KIF2C in BRCA, with a Pearson correlation of 0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUZ12→partner) and Y-score (partner→SUZ12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF2C →	+1.436	+0.334	<.001	<.001	3	9
HNSC	GINS1 →	+0.874	+0.240	<.001	.001	3	8
HNSC	MCM3 →	+1.075	+0.202	<.001	<.001	3	8
GBM	LMNB1 →	+1.040	+0.400	<.001	<.001	3	8
UCEC	CDC20 →	+1.616	+0.199	<.001	.002	3	8
BRCA	NCAPH →	+0.915	+0.328	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,274 associations by consensus.

SUZ12 vs KIF2C — BRCA

Explore this scatter interactively →