SUZ12

Across TCGA cell cohorts, SUZ12 mutation is significantly associated with the RNA expression of many other genes, with 90 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SUZ12-associated genes across cancer lineages are RAX, OR4E2, and KDM4E. Each is linked with SUZ12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUZ12-to-partner and partner-to-SUZ12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAX grouped by SUZ12-low versus SUZ12-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUZ12→partner) and Y-score (partner→SUZ12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RAX →	+0.436	+3.866	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR4E2 →	+0.017	+3.544	.003	.009	3	2
LUNG_NSCLC_LUAD	KDM4E →	+0.466	+4.093	<.001	.004	3	2
CNS	KRTAP20-2 →	+0.301	+4.472	<.001	.004	3	2
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	2
LUNG_SCLC	MYOC →	+0.038	+3.736	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

RAX by SUZ12 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →