SUSD3

Across TCGA patient cohorts, SUSD3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUSD3-associated genes across cancer lineages are 4E-BP1_pT37_T46, eEF2, and ERK2. Each is linked with SUSD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SUSD3-to-partner and partner-to-SUSD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by SUSD3-low versus SUSD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUSD3→partner) and Y-score (partner→SUSD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.608	-3.000	.005	.037	3	1
UCEC	eEF2 →	+0.429	+3.000	.038	.037	1	1
UCEC	ERK2 →	+0.261	+3.000	.018	.037	1	1
UCEC	JNK2 →	+0.319	+3.000	.005	.037	1	1
UCEC	Ku80 →	+0.284	+3.013	.037	.019	1	1
UCEC	TFRC →	+0.826	+3.000	.007	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

4E-BP1_pT37_T46 by SUSD3 expression — UCEC

Explore this box plot interactively →