SUSD3

Across TCGA pan-cancer cohorts, SUSD3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SUSD3 data layer compared with 5 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SUSD3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SUSD3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

BRCA, HNSC, and SKCM are the cancer types where SUSD3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.952	0.895	<.001	113	view →
HNSC	DFS	Quartile	All	0.803	0.619	<.001	71	view →
SKCM	OS	Median	All	0.443	0.248	<.001	64	view →
LUAD	OS	Tertile	All	0.759	0.607	<.001	61	view →
MESO	OS	Quartile	All	0.483	0.177	.003	60	view →
CESC	DFS	Quartile	II,III,IV	0.763	0.404	.008	30	view →
THCA	DFS	Median	All	0.882	0.768	.014	27	view →
LIHC	OS	Median	All	0.445	0.674	<.001	27	view →
OV	OS	Median	II,III,IV	0.659	0.717	.014	24	view →
READ	DFS	Quartile	IV	0.885	0.219	.002	24	view →
LGG	DFS	Quartile	All	0.377	0.577	.001	20	view →
THYM	OS	Median	All	1.000	0.665	.007	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SUSD3–BRCA (OS)

Open the BRCA breakdown →