SURF1

Across TCGA patient cohorts, SURF1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SURF1-associated genes across cancer lineages are Notch1, VHL, and Caspase-8. Each is linked with SURF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SURF1-to-partner and partner-to-SURF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SURF1-low versus SURF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SURF1→partner) and Y-score (partner→SURF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.195	+3.000	.016	.037	3	1
UCEC	VHL →	-0.908	-3.000	.020	.037	3	1
UCEC	Caspase-8 →	-0.358	-2.973	.013	.035	3	1
UCEC	p62 Lck ligand →	+0.457	+3.000	.015	.037	2	1
UCEC	BRCA2 →	-0.155	-2.992	.034	.036	2	1
UCEC	MEK1 →	+0.565	+3.000	.007	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Notch1 by SURF1 expression — UCEC

Explore this box plot interactively →