SUPT6H

Across TCGA patient cohorts, SUPT6H mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUPT6H-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and Claudin-7. Each is linked with SUPT6H in more than 4 cancer types. Because this analysis shows association rather than direction, both SUPT6H-to-partner and partner-to-SUPT6H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SUPT6H-low versus SUPT6H-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUPT6H→partner) and Y-score (partner→SUPT6H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.236	+2.815	<.001	.001	3	5
UCEC	PCNA →	+0.186	+1.736	.004	.006	3	4
COAD	Claudin-7 →	+0.809	+2.815	.001	.001	3	4
BLCA	FoxM1 →	+0.231	+2.842	.015	.033	3	3
UCEC	INPP4B →	-0.271	-2.392	.005	<.001	3	3
UCEC	Notch1 →	+0.124	+1.530	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Caspase-7-cleavedD198 by SUPT6H expression — COAD

Explore this box plot interactively →