SUPT6H

Across TCGA pan-cancer cohorts, SUPT6H RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SUPT6H data layer compared with 14 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SUPT6H RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SUPT6H expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

BLCA, KIRC, and ACC are the cancer types where SUPT6H RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Quartile	All	0.265	0.525	<.001	83	view →
KIRC	OS	Median	All	0.719	0.540	<.001	75	view →
ACC	DFS	Median	All	0.258	0.639	<.001	66	view →
LIHC	DFS	Median	All	0.455	0.626	<.001	63	view →
MESO	OS	Median	III,IV	0.448	0.660	.002	41	view →
LGG	OS	Tertile	All	0.310	0.563	<.001	39	view →
OV	OS	Quartile	II,III,IV	0.319	0.440	.008	38	view →
BRCA	DFS	Quartile	III,IV	0.664	0.316	.001	36	view →
PAAD	OS	Quartile	All	0.639	0.304	.001	18	view →
COAD	DFS	Tertile	II,III,IV	0.712	0.820	.008	18	view →
LUSC	DFS	Median	III,IV	0.523	0.916	.009	18	view →
KICH	DFS	Median	III,IV	0.374	0.901	.009	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SUPT6H–BLCA (DFS)

Open the BLCA breakdown →