SUPT6H

Across TCGA cell cohorts, SUPT6H mutation is significantly associated with the RNA expression of many other genes, with 1,063 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SUPT6H-associated genes across cancer lineages are PPP4R3A, EXOSC9, and MUTYH. Each is linked with SUPT6H in more than 1 cancer types. Because this analysis shows association rather than direction, both SUPT6H-to-partner and partner-to-SUPT6H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP4R3A grouped by SUPT6H-low versus SUPT6H-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUPT6H→partner) and Y-score (partner→SUPT6H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP4R3A →	+0.426	+3.064	.003	.009	3	2
LARGE_INTESTINE	EXOSC9 →	+0.638	+3.169	<.001	.006	3	2
LARGE_INTESTINE	MUTYH →	+0.641	+2.043	.002	.008	3	2
LARGE_INTESTINE	TUT4 →	+0.870	+2.743	.003	.001	3	2
LARGE_INTESTINE	NUP54 →	+0.509	+2.043	<.001	.008	3	2
LARGE_INTESTINE	RPRD1A →	+0.547	+3.321	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,063 associations by consensus.

PPP4R3A by SUPT6H expression — LARGE_INTESTINE

Explore this box plot interactively →