SUPT20H

Across TCGA patient cohorts, SUPT20H mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SUPT20H-associated genes across cancer lineages are Caspase-7-cleavedD198, BRD4, and eEF2. Each is linked with SUPT20H in more than 3 cancer types. Because this analysis shows association rather than direction, both SUPT20H-to-partner and partner-to-SUPT20H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SUPT20H-low versus SUPT20H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SUPT20H→partner) and Y-score (partner→SUPT20H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.799	+2.720	<.001	.003	3	4
UCEC	BRD4 →	+0.262	+3.321	.009	.009	3	3
UCEC	eEF2 →	+0.451	+2.247	<.001	.001	3	2
UCEC	ERK2 →	+0.246	+1.847	<.001	.008	3	2
UCEC	ACVRL1 →	-0.151	-1.680	.002	.042	3	2
UCEC	MEK1 →	+0.456	+2.736	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Caspase-7-cleavedD198 by SUPT20H expression — UCEC

Explore this box plot interactively →