SUPT20H

Across TCGA pan-cancer cohorts, SUPT20H RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SUPT20H data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SUPT20H RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SUPT20H expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

ACC, CESC, and ESCA are the cancer types where SUPT20H RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.380	0.771	<.001	68	view →
CESC	DFS	Tertile	All	0.393	0.702	<.001	46	view →
ESCA	DFS	Tertile	III,IV	0.267	0.494	.017	35	view →
KIRC	DFS	Tertile	IV	0.156	0.446	.006	34	view →
UVM	DFS	Quartile	III,IV	0.170	0.814	.001	30	view →
LIHC	OS	Median	III,IV	0.468	0.735	.008	28	view →
UCEC	OS	Median	III,IV	0.670	0.500	.027	26	view →
SCLC	OS	Quartile	III,IV	0.790	0.247	<.001	25	view →
GBM	OS	Quartile	All	0.647	0.286	.001	21	view →
UCS	DFS	Tertile	II,III,IV	0.545	0.092	.006	18	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.409	.006	14	view →
BLCA	OS	Tertile	II,III,IV	0.572	0.376	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SUPT20H–ACC (DFS)

Open the ACC breakdown →